Sometimes malware will slip past AV and other protection (that's why they have to issue updated definitions) and then deflect cleaners like MBAM, so it's recommended to run a program like RogueKiller (secondary download site, and official tutorial)... it will stop suspicious programs and allow your malware cleaners and AV programs to remove the infection(s). i.e. after RogueKiller does its scan and stops the rogue process(es), run MBAM or other 'cleaners' without rebooting or even quitting RogueKiller.

Note the official tutorial is in that first post, not its embedded video. And where it says "Quit all programs" that includes BOINC Client and Manager (using File->Exit, and check the box next to 'Stop running science applications..." in the dialog that pops up) - otherwise RogueKiller will see the application(s) as 'rogue' and stop them anyway. In my experience, RogueKiller stopping the task application(s) doesn't damage the results (you just lose the crunching time since the last checkpoint(s)), but I figure why risk it.