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World Community Grid Forums
Category: Completed Research
Forum: Help Cure Muscular Dystrophy - Phase 2 Forum
Thread: update and merry christmas |
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Thread Status: Active Total posts in this thread: 12
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Dear All,
a short upgrade in this Christmas evening to say once more thank you and to give you some idea of what we are doing at the moment. We are ultimating the analysis on the data obtained on phase 1 and hopefully we shall give you some update on this soon. We also started the tests on the prediction of co-evolution signals between protein interfaces. Roughly, we study the hypothesis that during its evolution a protein that changed a residue on its interface induced residue changes also on the interface of the partner. We should be able to trace these changes that occurred between partners. We know this observation to be true for several protein pairs but we are trying to refine our method for a large scale analysis to apply it afterwards to the set of proteins you are docking. This approach, combined with other results, should help to sharply discriminate between protein partners and proteins that do not interact. A Merry Christmas and a Happy New Year plenty of health and success to everyone from the scientists of the HCMD project, Alessandra |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Hi Alessandra.
A Merry Christmas to you and all working on this project. |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Dear Alessandra
Many thanks as always for your updates ! Wiish you also a Merry Christmas and a Happy New Year , health and a lot of success !!  |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
 Merry Christmas! Lawrence |
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rilian
Veteran Cruncher Ukraine - we rule! Joined: Jun 17, 2007 Post Count: 1452 Status: Offline Project Badges: 
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Hello! Merry X-Mas and Happy crunching in new year!
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KerSamson
Master Cruncher Switzerland Joined: Jan 29, 2007 Post Count: 1670 Status: Offline Project Badges:
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Dear Alessandra,
----------------------------------------Thank you for this update. I (we) wish you and your team a great Christmas time and a happy, healthy and successfully year 2011. Kind regards, Yves |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Molte grazie e buon Natale Alessandra :)
And Merry Christmas to all here on WCG! |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Hello WCG
Attention: Alessandra Carbone -- Help Cure Muscular Dystrophy Scientist Reference: Alessandra Carbone (Dec 24, 2010 9:48:25 PM) post Greetings I would like to know more; specifically: How does the capability to "sharply discriminate between protein partners and proteins that do not interact" help advance the science or the search for a solution? Would the scientist, if armed with the said capability, now select only those proteins that interact as candidates for docking calculations? -- in which case the (hoped-for) advancement is in terms of speedup (by not having to dock-calculate the type that is not likely to lead to a solution). Or is the (hoped-for) advancement more in terms of some qualitative insight as to the characterization of the difference in the protein types (interacting vs. non-interacting) with both types qualified as candidates for docking calculations? Good day and Merry Christmas everyone! ; |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Hi, we still need to cross co-evolution with energy. we are there at the moment. docking is therefore important.
Cheers! Alessandra |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Hi andzgrid,
Here is my opinion of biological research. You have a long list of, for example, 1400 proteins. You can view each protein as a gear and study the teeth, their shape and size and placement. But you can also learn which other gears they interact with. Eventually you might group each gear into a machine and convert the list of 1400 proteins (gears) into a much smaller list of machines. Then you might study how these machines interact and regulate each other and how they can go wrong. Lawrence |
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