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World Community Grid Forums
Category: Completed Research
Forum: FightAIDS@Home
Thread: ... and if you find something ... |
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Thread Status: Active Total posts in this thread: 16
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mgl_ALPerryman
FightAIDS@Home, GO Fight Against Malaria and OpenZika Scientist USA Joined: Aug 25, 2007 Post Count: 283 Status: Offline Project Badges: 
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Dear esoteric17 and V/R Nasher,
You are very welcome. I'm glad that my long-winded posts did some good. Best wishes, Dr. Alex Perryman PS--details related to the above discussion are presented in Volume 8 of the FAAH Newsletter, which I just posted on-line. |
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pball1224
Cruncher USA Joined: Nov 22, 2005 Post Count: 45 Status: Offline Project Badges: 
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I also would like to thank you for the explanation, as well as the reply to the further questions, rather than simply ignoring it. I found it all VERY informative! I wish WCG Forums would have more information such as this, or at least keep it at the top of the list of threads. I find it much more interesting than a thread about who has badges... except maybe in the last few days of a project
 But in all seriousness, it's posts like this that remind me that the extra on my electric bill is going to a good cause, and is in fact in the public domain. If your organization gets a couple months head start on the next stage of research, I'm still pretty comfortable with that, as I think you probably deserve a little something for taking the initiative to put the project together. A month or two in what takes many years to fully research doesn't seem to be a hugely unfair advantage. Just my two cents, Thanks again. |
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steffen_moeller
Cruncher Joined: Dec 3, 2005 Post Count: 44 Status: Offline |
Dear Alex,
as the original poster I also want to thank you - and to forward you the thanks of the "friendly folks" whose comments made me post my question in the first place. There was something that stimulated me a lot in your reply which is somewhat unrelated to my original request: I don't know about what you have done to evaluate the performance of the hits in the wet-lab, or about how many there are. But if you have some sort of quantitative score to indicate the degree of "success" of your substances, maybe together with a positive control experiment of some known drug, or an indication about what substance worked for real on what variant, then I could imagine the effort to be helpful in finding better models. I agree that you cannot publish it highly, but everyone interested in methods for docking, at Scripps and throughout the globe, may be highly interested ... and as such you can probably place some paper fairly straight-forwardly at some place you know better than I do. Many thanks again Steffen |
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mgl_ALPerryman
FightAIDS@Home, GO Fight Against Malaria and OpenZika Scientist USA Joined: Aug 25, 2007 Post Count: 283 Status: Offline Project Badges:
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Dear Steffen,
You are very welcome. I'm glad that my responses helped ameliorate your concerns. And thank you for posting your questions--they motivated me to address some issues that certainly needed attention. Regarding the wet lab tests performed by our collaborators at TSRI to assess the performance of the hits discovered on FightAIDSatHome, please see the latest 2 volumes of the FAAH newsletter (i.e., Volumes 7 and 8). As a reference, the FDA-approved HIV protease drugs tend to display IC50 values in the low nano-Molar to sub-nano-Molar range against the wild type protease (i.e., the current drugs are 1,000 to 100,000 times more potent than what we call "hits"). These two volumes also discuss the new strategies we are using when analyzing the computational results. Thank you for your help, Dr. Alex L. Perryman PS--Steffen, thank you very much for all of the hard work you do with Ubuntu. Ubuntu is a great, free, easy-to-use and easy-to-update version of linux of which I am now quite fond. Kudos to you! |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Thanks for the detailed answers! It was hard to find clear statements about FAAH and patents before I found this thread. After reading it, I decided not to crunch for FAAH. I don't want to lower the big pharma R&D expenses while they are still selling their drugs for the same high prices thanks to their patent-based monopoly.
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vlado101
Senior Cruncher Joined: Jul 23, 2013 Post Count: 226 Status: Offline Project Badges:
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Thank you for your in-depth explanation Dr. Perryman.
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