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World Community Grid Forums
Category: Completed Research
Forum: Human Proteome Folding
Thread: Introduction to Folding Proteins for New Members |
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Thread Status: Active Total posts in this thread: 23
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Are the shapes of these conjugated proteins influenced by the sugars, fats or nucleic acids? Yes. In the end, they're all basically nitrogen, carbon, hydrogen and oxygen molecules, with the addition of the occassional 'exotic' element like iron, magnesium, or so on. And if so, are these sugars, fats or nucleic acids comprehended in the Rosetta computer modeling program? I should think so. In the end, they're all basically covalently and ionically bonded molecules. [Edit 1 times, last edit by Former Member at Feb 1, 2005 5:40:31 AM] |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Hi mondaypuppy,
Two Questions: Are the shapes of these conjugated proteins influenced by the sugars, fats or nucleic acids? And if so, are these sugars, fats or nucleic acids comprehended in the Rosetta computer modeling program? This will have to wait until the new Forum monitored by the ISB scientists goes active. But if you read the scientific articles discussing the protein designs created by Rosetta and similar programs, they seem to discuss post-processing by both computer and human to produce modified designs, and various measures comparing the computed NMR signatures with actual NMR signatures. I suspect that there are almost endless complexities that molecular biologists have to face, and that you are correctly recognizing some of their problems. Lawrence |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Thank you for sharing your expertise in this facinating subject.
Peeling the onion one more layer, are these "baggage molecules" (sugars, fats or nucleic acids) specified in the gene sequencing along with amino acids? I suspect not. If not, then short of direct observation of known proteins, is there a standardized way to predict exactly the type and location where each baggage molecule attaches? |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
 Hi mondaypuppyYou may find some answers at the following links http://en.wikipedia.org/wiki/Protein_folding http://en.wikipedia.org/wiki/Protein http://en.wikipedia.org/wiki/Amino_acid Regards |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Mondaypuppy,
are these "baggage molecules" (sugars, fats or nucleic acids) specified in the gene sequencing along with amino acids? I suspect not. If not, then short of direct observation of known proteins, is there a standardized way to predict exactly the type and location where each baggage molecule attaches? This is definitely beyond anything I can answer. However, starting around 1979, 'monoclonal antibodies' were in all the news. Wall Street started throwing money at lots of new 'biotech' firms that were going to insert genes into yeast and produce vast numbers of medically important biochemicals in vats. Time passed. . . . . more time passed. In the mid-1990s I started reading a few articles that said that a lot of experiments in the 1980s had run into an unexpected roadblock. Some biochemicals produced in yeast, supposedly of the same formula as used in mammals, produced massive allergy reactions and even immune system fever and shock when injected into mice and rabbits. The sugars attached to these molecules were quite different in yeast and mammals and this difference was noticed by the immune system. In retrospect, it made lots of sense for the immune system to be able to differentiate between own-species molecules and those produced by invading bacteria, fungi and yeast. But I do not know how standardized these attachments are or what scientists have learned about them in the last generation. Lawrence |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Thank you so much! It appears we've reached the Protein research frontier!
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A&Rmassey
Cruncher Joined: Nov 17, 2004 Post Count: 5 Status: Offline |
Thanks for taking the time to research and pass on this info. It is a great read and very illuminating. Mother Nature has some amazing tricks up her sleeve! Your effort is appreciated. Thanks.
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Back in the spotlight for the benefit of the new members |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Back in the spotlight for the benefit of the new members |
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nealschim
Cruncher Joined: Nov 24, 2005 Post Count: 14 Status: Offline |
Thanks for this concise and interesting information. Great work !
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