First, a non-profit organization has to have a research project which benefits humanity for which they require some serious computer power in order to complete the research.

Then someone from the research organization goes to the World Community Grid RFP page and completes the Request for Proposal form and sends it to World Community Grid: http://www.worldcommunitygrid.org/about_us/request_for_proposals.html

At World Community Grid, we review the RFP to ensure it meets all requirements and is technically feasible to run on the grid. A final approval comes from the Advisory Board: http://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,27722